If you’re engaged in the world of optimal nutrition and supplementation then chances are you’ve heard of Mitopure, Timeline Nutrition’s signature product to combat the negative effects of aging. Through the key ingredient Urolithin A, Mitopure is used in various skincare and nutrition products to improve the health of our skin, bones, and joints by energizing cells and promoting mitophagy and mitochondrial function. Studies about the effects of Urolithin A have been numerous, showing how the compound can reduce inflammation and improve mitochondrial health in the joints of both healthy donors and osteoarthritis patients.
As scientists continue to study the effects of Urolithin A and its potential for fighting age-related cell decline, we’re seeing a positive correlation between UA and brain health. Cognitive decline is among our greatest fears. Anything we can do to keep our brains healthy and fight cognitive decline will have major consequences for our quality of life as we age, which is why the research surrounding Urolithin A and brain health is so promising.
In one study published in December 2022, scientists investigated the effects of UA in mice as an autophagy activator with potential neuroprotective activity. Because UA has shown significant success in promoting mitophagy in skin cells and our joints, it stands to reason that it would have similar results in the cells in our brains. Over the course of the study, UA was found to “prevent deficits in spatial memory, cued fear response, and exploratory behavior.” They also found that UA was able to extend the lifespan in normal, aging mice, a significant discovery when combined with its potential to prevent the onset of cognitive defects.
Additional studies in mice have shown how Urolithin A even holds the potential to treat Alzheimer’s Disease, a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. A study performed in March 2019 showed that UA “imparted cognitive protection by protecting neurons from death and triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice, suggesting that UA might be a promising therapeutic drug to treat AD.” Researcher Julie Andersen from the Buck Institute for Research on Aging has also performed extensive research to determine the connection between the health of the gut microbiome and the prevention or reversal of age-related dementia, discovering another possible link between UA and brain health.
While many of the studies regarding Urolithin A have been performed on mice, they show significant promise for the compound’s effect on humans. As a natural compound promoting mitophagy and mitochondrial function, UA holds the potential to improve health in numerous ways, some of which are still being discovered. From skin health to longevity to neuroprotection, UA is quickly revealing itself to be a major asset in the fight against the diseases of aging.