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Urolithin A and Brain Health: How Mitopure’s Key Ingredient Might Help Slow Cognitive Decline

As scientists continue to study the effects of Urolithin A on aging, we are beginning to see how UA may impact brain health.

If you’re engaged in the world of optimal nutrition and supplementation then chances are you’ve heard of Mitopure, Timeline Nutrition’s signature product to combat the negative effects of aging. Through the key ingredient Urolithin A, Mitopure is used in various skincare and nutrition products to improve the health of our skin, bones, and joints by energizing cells and promoting mitophagy and mitochondrial function. Studies about the effects of Urolithin A have been numerous, showing how the compound can reduce inflammation and improve mitochondrial health in the joints of both healthy donors and osteoarthritis patients.

As scientists continue to study the effects of Urolithin A and its potential for fighting age-related cell decline, we’re seeing a positive correlation between UA and brain health. Cognitive decline is among our greatest fears.  Anything we can do to keep our brains healthy and fight cognitive decline will have major consequences for our quality of life as we age, which is why the research surrounding Urolithin A and brain health is so promising.

In one study published in December 2022, scientists investigated the effects of UA in mice as an autophagy activator with potential neuroprotective activity. Because UA has shown significant success in promoting mitophagy in skin cells and our joints, it stands to reason that it would have similar results in the cells in our brains. Over the course of the study, UA was found to “prevent deficits in spatial memory, cued fear response, and exploratory behavior.” They also found that UA was able to extend the lifespan in normal, aging mice, a significant discovery when combined with its potential to prevent the onset of cognitive defects.

Additional studies in mice have shown how Urolithin A even holds the potential to treat Alzheimer’s Disease, a progressive neurodegenerative disorder characterized by an abnormal accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and impaired neurogenesis. A study performed in March 2019 showed that UA “imparted cognitive protection by protecting neurons from death and triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice, suggesting that UA might be a promising therapeutic drug to treat AD.” Researcher Julie Andersen from the Buck Institute for Research on Aging has also performed extensive research to determine the connection between the health of the gut microbiome and the prevention or reversal of age-related dementia, discovering another possible link between UA and brain health.

While many of the studies regarding Urolithin A have been performed on mice, they show significant promise for the compound’s effect on humans. As a natural compound promoting mitophagy and mitochondrial function, UA holds the potential to improve health in numerous ways, some of which are still being discovered. From skin health to longevity to neuroprotection, UA is quickly revealing itself to be a major asset in the fight against the diseases of aging.

Timeline Nutrition has offered a special discount for our readers. Use code “AGEIST” at checkout and receive 10% off their products.

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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.

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