A recent study demonstrates that SARS-CoV-2, the virus responsible for COVID-19, has an impact on DNA integrity and elicits an altered DNA damage response. Specifically, two viral proteins (ORF6 and NSP13) cause degradation of the DNA damage response kinase CHK1, leading to a shortage of deoxynucleotide triphosphate (dNTP). This shortage impairs DNA replication and repair, leading to DNA damage, activation of pro-inflammatory pathways, and cellular senescence. The virus’ N-protein further interferes with damage-induced long non-coding RNAs, reducing DNA repair. These findings were observed in both infected mice and COVID-19 patients, indicating that SARS-CoV-2 poses a threat to genome integrity and induces altered DNA damage response, inflammation, and cellular senescence by manipulating cellular processes.
Covid Damages DNA
Join the AGEIST movement!
Sign-up for our weekly magazine.
See medical disclaimer below.
The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.