A global study co-led by researchers from The University of Queensland and Harvard Medical School reveals that one in two individuals will experience a mental health disorder during their lifetime. The study examined data from over 150,000 adults across 29 countries between 2001 and 2022, showing that 50% of people will develop at least one mental disorder by age 75. Mood disorders like major depression and anxiety were the most prevalent, with varying risks based on gender. Among women, the most common disorders were depression, specific phobia, and post-traumatic stress, while men commonly experienced alcohol abuse, depression, and specific phobia. Onset of these disorders typically occurs in childhood, adolescence, or early adulthood, with an emphasis on investing in neuroscience and mental health services, especially for young individuals. The findings contribute important insights for designing targeted interventions and allocating resources to support those at risk.