Welcome to Our Weekly Magazine

Become the best version of yourself Sign-up for our weekly magazine.

Become the best version of yourself today.

We send a weekly roundup of our best work and highlight standout community members. It's free, and you can always leave if it's not your jam.

New Compound to Enhance Mitochondria Health

Researchers at the Buck Institute have discovered a new compound, Mitophagy-Inducing Compound (MIC), which enhances the health of mitochondria, the energy-producing organelles in cells. This natural coumarin, found in cinnamon and possessing various beneficial properties, extended the lifespan of C. elegans, improved neurodegenerative disease models, and enhanced mitochondrial function in mouse muscle cells. Published in Nature Aging on November 13, 2023, the study explores the impact of mitochondrial dysfunction on age-related diseases such as Parkinson’s, Alzheimer’s, heart failure, obesity, diabetes, muscle wasting, and cancer. MIC activates the transcription factor TFEB, a key regulator of autophagy and lysosomal functions, leading to increased lifespan in C. elegans and preventing mitochondrial dysfunction in mammalian cells. The compound also inhibits FXR, linking the gut microbiome, bile acids, and neuronal health, offering potential therapeutic avenues for various age-related conditions. MIC is considered a promising geroprotective therapeutic, addressing the bottleneck in geroscience drug development.


See medical disclaimer below.

The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.