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Link Between Memory & Appetite to Explain Obesity

New research from the Perelman School of Medicine at the University of Pennsylvania reveals that disrupted connections between brain circuits responsible for memory and appetite regulation are closely associated with body mass index (BMI), especially in individuals with eating disorders like binge eating disorder (BED) and obesity. This study, published in Nature, highlights that obese individuals exhibit impaired connections between the dorsolateral hippocampus (dlHPC) and the lateral hypothalamus (LH), affecting their ability to control emotional responses when anticipating rewarding meals. The dlHPC handles memory processing, while the LH maintains bodily stability (homeostasis). The research employed electrical brain monitoring in patients anticipating sweet treats and found that both the dlHPC and LH activated together, with stronger connectivity in obese individuals correlating with higher BMI. Brain tissue analysis confirmed a link between these regions through the presence of the feeding behavior-regulating melanin-concentrating hormone (MCH) in the dlHPC. This study suggests potential for identifying at-risk individuals and developing innovative therapies targeting these brain circuits to combat obesity and related eating disorders.

Study

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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.