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How to Live to Over 110 & Be Healthy: Dr. Michael Roizen

Should we take aspirin every day? What do we need to know about cholesterol and statins? What level of cholesterol is healthy? What is epigenetics? What is the effect of stress on our epigenetics? What is the effect of stress on our microbiome? How did therapeutic plasma exchange make mice younger and how is this technology being used for humans? 

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Dr. Michael Roizen is the Chief Wellness Officer Emeritus at Cleveland Clinic, award-winning author, and founder of RealAge. Dr. Roizen joins us to discuss his new book The Great Age Reboot, how stress impacts our health, what numbers we should aim for for cholesterol, therapeutic plasma exchange, and more. 

“Stress, it turns out, turns on genes that make proteins that cause inflammation. Moderating stress — that is, happiness — turns off those same genes and turns on genes that make anti-inflammatory proteins — proteins that decrease inflammation.” 

“The most important things are posse and purpose: having 6 friends you’re vulnerable to every month, having a purpose in life, and a job with latitude.” 

“When you exercise, you change the genes that are on in your microbiome. When you’re stressed, you change which genes are on in your microbiome.” 

“I still think you should shoot for cholesterol less than 70 in your blood.” 

“The most important things you do for brain health are posse and purpose, that’s one. The second one is to add speed to your exercise, that is to stress your muscle; and the third is to add speed to your brain games.” 

Listen to the SuperAge podcast wherever you get your pods. 

Connect with Dr. Michael Roizen
Buy “The Great Age Reboot: Cracking the Longevity Code for a Younger Tomorrow” 

See medical disclaimer below. ↓


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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.


Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.


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