Scientists at the University of Reading researched the connection between high doses of vitamin B6 & depression and anxiety. They found that “Vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain, and our study links this calming effect with reduced anxiety among the participants.” This is due to vitamin B6’s ability to increase “the body’s production of GABA” which is a chemical that “blocks impulses between nerve cells in the brain.” Food sources of vitamin B6 include “tuna, chickpeas and many fruits and vegetables” however the study found that in order to have the positive effects on mood, high doses of B6 through supplementation are needed.

https://www.reading.ac.uk/news/2022/Research-News/Vitamin-B6-could-reduce-anxiety-and-depression