The process of cell reprogramming involves a shift from cellular identity to an embryonic stem cell-like state, activated by four specific genes. Scientists are exploring transient reprogramming as a potential strategy for tissue rejuvenation and regeneration. However, this process is not well-understood, exhibiting low efficiency and posing risks such as teratoma and cancer development. A recent study has revealed that mice undergoing cellular reprogramming experience a widespread depletion of vitamin B12. When supplemented with B12, not only did the reprogramming efficiency improve, but tissue repair was also accelerated in a mouse model of ulcerative colitis. The researchers suggest that “our findings…underscore the potential to safely administer B12 for enhancing cellular plasticity in therapeutic applications for regenerative medicine, organ injury, and repair.”Further research is necessary to ascertain the applicability of these results to humans.
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Vitamin B12 Boosts Tissue Repair
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