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The Positive Impact of Endurance and Resistance Training on Mitochondrial Function

The aging process is associated with sarcopenia, a condition characterized by declining muscle function and mass, which is linked to mitochondrial dysfunction and reduced energy generation in skeletal muscle. While there has been debate about whether these changes are primarily caused by aging itself or by increased sedentary behavior, research shows that exercise can effectively counteract these declines through various mechanisms, including improved mitochondrial coupling efficiency and reduced oxidative stress.

Both endurance training (ET) and resistance training (RT) offer unique benefits. ET increases mitochondrial biogenesis and oxidative capacity, while RT enhances muscle mass and improves coupling efficiency without necessarily increasing mitochondrial volume. Concurrent training (CT), which combines both RT and ET, appears to provide the most comprehensive benefits, with studies suggesting that performing resistance training followed by endurance training may be the optimal sequence. The evidence suggests that a combination of moderate-to-high repetition resistance training followed by alternating high and moderate intensity endurance training could be most effective in reversing age-related mitochondrial dysfunction and preserving muscle function in older adults.

Read the science here.

Image credit: Jacob Wackerhausen / iStock

See medical disclaimer below.

The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.