Peter Attia of the Peter Attia Drive podcast is joined by Matt Kaeberlein, globally recognized researcher, to dive into the various definitions of aging, rapamycin, fasting, mTOR, and inflammation’s role in health and disease. They discuss the current state of the literature of testing rapamycin (and rapalogs) in animals and humans, including Matt’s Dog Aging Project, and provide insights into how we can improve future trials by conceptualizing risk, choosing better endpoints, and working with regulators to approve such trials. With new studies and research coming out about how we can effectively intervine in the aging process, it can be overwhelming. Matt leaves us with some wisdom: “I don’t think I will ever understand aging fully. And I don’t think the field will. … But I also believe that we don’t have to understand it fully to be able to have an impact on the biology of aging through interventions.” — Matt Kaeberlein