It is clear that mentally stimulating activities and life experiences can improve cognition in memory clinic patients. However, a new study from Karolinska Institute shows that stress undermines this beneficial relationship. The researchers examined cognitive reserve, cognition, and Alzheimer’s biomarkers in 113 memory clinic patients. They found that greater cognitive reserve improved cognition but physiological stress weakened this association. High or persistent stress levels are linked to reduced social interactions, impaired ability to engage in activities, and increased dementia risk. Lead author Manasa Shanta Yerramalla suggests stress management strategies like mindfulness could complement lifestyle interventions for Alzheimer’s prevention. The small sample limits robust conclusions; however, the results generalize to similar patient groups.
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Stress Can Diminish Cognitive Reserve
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