A new study from Mass General Cancer Center found that statins, cholesterol-lowering drugs, may block a pathway involved in cancer development caused by chronic inflammation. Environmental toxins were shown to activate signaling pathways. This leads to production of the interleukin-33 (IL-33) protein, which stimulates inflammation in the skin and pancreas. This contributes to cancer. Remarkably, the researchers discovered the statin drug pitavastatin effectively suppresses IL-33 by blocking the TBK1-IRF3 pathway. In mouse models, pitavastatin suppressed environmentally-induced inflammation and prevented pancreatic cancer development. Analysis of health records data links pitavastatin use to a significantly reduced risk of chronic pancreatitis and pancreatic cancer in humans.
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Statins May Help Prevent Cancer
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