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Semaglutide May Improve Symptoms of Heart Failure, in Addition to Weight Loss

The groundbreaking STEP-HFpEF study, presented at the American Diabetes Association’s 2024 Scientific Sessions, reveals that semaglutide, originally developed for diabetes and obesity, significantly improves symptoms in both men and women with heart failure with preserved ejection fraction (HFpEF). This medication demonstrates benefits beyond weight loss, suggesting potential direct effects on the cardiovascular system. Notably, women in the study experienced greater weight loss than men and had worse baseline symptoms, highlighting important sex differences in obesity-related HFpEF. Semaglutide improved heart failure-related symptoms, physical limitations, and exercise function similarly in both sexes, while also reducing inflammation and natriuretic peptides. These findings underscore the importance of recognizing and addressing sex-specific differences in HFpEF, a condition that disproportionately affects women and has historically had limited treatment options.


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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.