The groundbreaking STEP-HFpEF study, presented at the American Diabetes Association’s 2024 Scientific Sessions, reveals that semaglutide, originally developed for diabetes and obesity, significantly improves symptoms in both men and women with heart failure with preserved ejection fraction (HFpEF). This medication demonstrates benefits beyond weight loss, suggesting potential direct effects on the cardiovascular system. Notably, women in the study experienced greater weight loss than men and had worse baseline symptoms, highlighting important sex differences in obesity-related HFpEF. Semaglutide improved heart failure-related symptoms, physical limitations, and exercise function similarly in both sexes, while also reducing inflammation and natriuretic peptides. These findings underscore the importance of recognizing and addressing sex-specific differences in HFpEF, a condition that disproportionately affects women and has historically had limited treatment options.
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Semaglutide May Improve Symptoms of Heart Failure, in Addition to Weight Loss
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