A recent study in Nature Communications reveals that fruit flies experience cognitive decline with age, similar to humans. Researchers found that the buildup of a cell structural protein called filamentous actin (F-actin) in the brains of aging fruit flies inhibits the cellular process that removes waste, therefore leading to diminished neuronal function. By modifying specific genes in these flies, the team successfully reduced F-actin accumulation, thereby enhancing cellular recycling and extending their healthy lifespan by about 30%. The study showed that preventing F-actin buildup improved not only brain function but also overall health, highlighting its detrimental role in age-related cognitive decline. These findings may guide future research on promoting healthier aging in humans by targeting mechanisms involved in cellular waste management.
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