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How Do Our Memories Last Forever?

A new study explains how long-term memories are formed and maintained in the brain. Researchers discovered that a molecule called KIBRA acts as a “glue” to other molecules, particularly protein kinase Mzeta (PKMzeta), which is crucial for strengthening synapses. KIBRA serves as a persistent synaptic tag, selectively attaching to strong synapses and PKMzeta while avoiding weak ones, thus allowing memories to endure despite the constant turnover of molecules in neurons. The study, conducted on laboratory mice, shows that disrupting the KIBRA-PKMzeta bond can erase old memories, while increasing PKMzeta can enhance weak or faded memories. This research affirms a concept proposed by Nobel Laureate Francis Crick in 1984, comparing memory storage to the maintenance of Theseus’ Ship, and provides insights that may help address memory-related disorders in the future.


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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.