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Gene Variant That May Guard Against Alzheimer’s Disease

A recent extensive study involving various ethnic groups has revealed that approximately 20% to 30% of individuals carry a specific immune-related gene variant, HLA-DRB1*04, which appears to offer protection against Alzheimer’s and Parkinson’s diseases. These individuals showed an 8% to 15% lower risk of developing these neurodegenerative conditions and exhibited fewer abnormal brain proteins associated with these diseases, such as tau tangles. The findings, published in PNAS, could have implications for the development of new vaccines targeting these diseases. Alzheimer’s and Parkinson’s are characterized by the loss of specific brain neurons and the accumulation of abnormal proteins, and this study suggests that immune genes may play a role in their development. Researchers hope to develop immunotherapies or vaccines based on these gene variants to delay disease onset or progression.


See medical disclaimer below.

The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.