Restricting calories has been linked to improved health and increased lifespan, with a particular focus on its impact on brain health. Scientists at the Buck Institute have identified a gene called OXR1 that plays a crucial role in the lifespan extension associated with dietary restriction and is essential for healthy brain aging. The research, conducted in fruit flies and human cells, reveals a detailed cellular mechanism through which dietary restriction can delay aging and slow neurodegenerative diseases. The study emphasizes the importance of this gene in brain resilience, protecting against aging and neurological diseases. The team also explored variability in individual responses to dietary restriction, identifying genes that significantly affect longevity. One gene, OXR1, was found to preserve retromer function, a mechanism crucial for recycling cellular proteins and lipids, thereby slowing brain aging. The findings suggest that dietary choices impact gene expression and cellular mechanisms, supporting the idea that a healthy diet can influence overall well-being.
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Dietary Restriction Slows Aging
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