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Colchicine and Cardiovascular Disease

Inflammation is a key factor in the development of cardiovascular diseases like atherosclerosis, and anti-inflammatory agents may enhance cardiovascular outcomes. Colchicine, a well-tolerated therapeutic traditionally used for conditions like gout and familial Mediterranean fever, possesses notable anti-inflammatory effects applicable to a wide range of cardiovascular diseases. It is a standard-of-care therapy for pericarditis, and various clinical trials have explored its potential in conditions such as postoperative and post-ablation atrial fibrillation, postpericardiotomy syndrome, coronary artery disease, percutaneous coronary interventions, and cerebrovascular disease. This summary aims to outline the pharmacodynamics and anti-inflammatory mechanisms of colchicine, provide an overview of existing evidence in cardiovascular disease treatment, and highlight ongoing randomized clinical trials. Despite its simplicity, low cost, and effectiveness, the real-world clinical implications of colchicine should be assessed based on completed trials’ merits and limitations. Ongoing research will further address questions related to the use of low-dose colchicine in treating cardiovascular diseases.

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See medical disclaimer below.

The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Taylor Marks
Taylor Marks is a certified holistic health coach and professionally trained chef from The Institute of Culinary Education. Her passions include the latest research in health science, culinary arts, holistic wellness, and guiding others towards feeling their best.