Inflammation is a key factor in the development of cardiovascular diseases like atherosclerosis, and anti-inflammatory agents may enhance cardiovascular outcomes. Colchicine, a well-tolerated therapeutic traditionally used for conditions like gout and familial Mediterranean fever, possesses notable anti-inflammatory effects applicable to a wide range of cardiovascular diseases. It is a standard-of-care therapy for pericarditis, and various clinical trials have explored its potential in conditions such as postoperative and post-ablation atrial fibrillation, postpericardiotomy syndrome, coronary artery disease, percutaneous coronary interventions, and cerebrovascular disease. This summary aims to outline the pharmacodynamics and anti-inflammatory mechanisms of colchicine, provide an overview of existing evidence in cardiovascular disease treatment, and highlight ongoing randomized clinical trials. Despite its simplicity, low cost, and effectiveness, the real-world clinical implications of colchicine should be assessed based on completed trials’ merits and limitations. Ongoing research will further address questions related to the use of low-dose colchicine in treating cardiovascular diseases.
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Colchicine and Cardiovascular Disease
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