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My Ultimate Skincare Routine Over 50

Looking to achieve better skincare results in fewer steps? Discover youthful skin with OneSkin's revolutionary products.

Something about the change in weather always makes me want to refresh my life—whether it’s swapping out my wardrobe or revamping my skincare routine. And this year, I wanted to streamline my beauty routine and find products that actually work. That’s why I tried OneSkin, a skincare brand making waves in the beauty world for its scientific approach to aging.

I’ve always believed that aging shouldn’t be synonymous with “outdated”—it’s about evolving, staying vibrant, and feeling confident in your skin. But, like many women, I’ve noticed my skin changing as I hit my 50s. Fine lines, dullness, and a general lack of that youthful glow have started creeping in. So when I heard about OneSkin, a brand developed by four female longevity scientists, I was intrigued.

Why OneSkin Stood Out

What drew me in? Their revolutionary OS-01 peptide. I’m no scientist, but I am a total skincare nerd, and the fact that this peptide was designed to work at a cellular level to slow aging—and even reverse the biological age of my skin1—caught my attention. It’s one thing to hydrate and moisturize, but to target damaged cells and promote healthy skin regeneration? I was all in.

Founded by four visionary longevity scientists, OneSkin aims to slow the aging process by addressing the root causes. With their combined experience in the skincare and longevity industries, these female founders leveraged their expertise to create a brand backed by over eight years of research, boasting over 6,300 glowing five-star reviews. But what really sets OneSkin apart in the crowded skincare market is their secret weapon: the revolutionary OS-01 peptide. This potent peptide was tested using MolClock, a tool that measures skin’s biological age. In lab studies after five days of treatment with OS-01 peptide, a human skin sample aged 70.88 years saw its age drop by 2.6 years, proving OS-01’s remarkable ability to rejuvenate the skin at the cellular level.1 

My OneSkin Skincare Routine

The star of the show for me has been the OS-01 FACE Topical Supplement. I love how it was designed to replace the layers and layers of serums and creams I used to rely on. Morning and night, I apply this lightweight moisturizer to my face, neck, and even hands. It’s a triple threat: hydrating, brightening, and reducing fine lines in one step.2 The simplicity was exactly what I needed, and my skin soaked it up. Within weeks, I noticed a newfound glow that I hadn’t seen in a while—and, honestly, one I wasn’t sure I’d ever get back.

Then there’s the OS-01 EYE Topical Supplement. I’ve always been skeptical about eye creams—are they worth it? But One Skin’s eye cream has completely converted me. It’s light and hydrating; with the highest concentration of the OS-01 peptide, a little dab goes a long way. After a few weeks, the puffiness under my eyes had disappeared, and the fine lines were much less noticeable. It’s now a staple in my routine. I feel refreshed and awake, even when I’ve skimped on sleep.

A Whole Body Experience

One Skin’s OS-01 BODY Topical Supplement has been another game changer. After my shower, I slather this luxurious cream on from head to toe. It’s become one of the best parts of my routine. Not only does it enhance the texture of my skin, but it also strengthens and fortifies my skin’s barrier, leaving it soft and resilient. For the first time in a long time, I don’t feel like my skin is dry or fragile. With colder months on the horizon, it’s especially important that my skin feels protected, which I hadn’t experienced with any other body lotion.

Finishing Touches with SPF

Of course, no skincare routine is complete without SPF, and OneSkin’s Tinted Mineral Sunscreen has been a lifesaver. It’s lightweight and doubles as a foundation, giving me that perfect no-makeup glow while providing broad-spectrum protection. It’s my go-to when I want to keep things simple but polished. (For those looking for a non-tinted version, they have that too.)

Sustainability and Simplicity

I also love that OneSkin doesn’t just care about skin—they care about the planet. Their PREP Facial Cleanser comes with refillable pouches, and it’s now a key part of my daily routine. It’s gentle yet effective, removing makeup and dirt without stripping my skin of its natural moisture. Plus, knowing I’m reducing waste while keeping my skin healthy is a total win.

Why I’m Hooked

What sets OneSkin apart is how easy it is to incorporate into my routine. Fewer steps, better results. I’m not overwhelmed with choices, and I don’t need to spend hours figuring out which products to use. And the results speak for themselves. Clinically tested and AGEIST-approved, OneSkin delivers science-packed products that are simple and effective.

As a bonus, they give back by continuously donating to Aging Forward, an initiative supporting lifelong learning, healthy living, and community building. It’s a feel-good factor that makes me proud to support the brand.

Ready to Try My Skincare Routine?

If you’re ready to simplify your skincare and invest in products that work at every age, OneSkin is for you. Because I love it so much, I’m thrilled to share an exclusive discount: Use code AGEIST15 for 15% off your first purchase. Trust me, your skin will thank you.

1 Zonari, A., Brace, L.E., Al-Katib, K. et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9, 10 (2023). https://doi.org/10.1038/s41514-023-00109-1

2 Zonari A., Brace, L.E., Harder, NHO, et al. Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation. J Cosmet Dermatol. 2024; 23: 2135-2144. doi:10.1111/jocd.16242

See medical disclaimer below. ↓

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The ideas expressed here are solely the opinions of the author and are not researched or verified by AGEIST LLC, or anyone associated with AGEIST LLC. This material should not be construed as medical advice or recommendation, it is for informational use only. We encourage all readers to discuss with your qualified practitioners the relevance of the application of any of these ideas to your life. The recommendations contained herein are not intended to diagnose, treat, cure or prevent any disease. You should always consult your physician or other qualified health provider before starting any new treatment or stopping any treatment that has been prescribed for you by your physician or other qualified health provider. Please call your doctor or 911 immediately if you think you may have a medical or psychiatric emergency.

Sheri Radel Rosenberghttps://unapologeticstyle.substack.com/
Sheri Radel Rosenberg is a Philly-born, Brooklyn-based writer who explores style, beauty, culture, and midlife with wit, warmth, and wisdom. Her story includes successful forays in the worlds of trend forecasting, ad agency photo production, ghostwriting, and strategic messaging development for fashion and beauty brands - all while amassing a slip dress collection that would make any Gen Xer proud. At the dawn of social media, Sheri launched her personal blog–which combines her passion for writing with her style obsession–and she hasn’t looked back. As Style Editor for the AGEIST, she’s inspired by the styles of the 70s and the 90s, along with all the beautiful people she sees daily in NYC.

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